Active Ingredient	Antihistamine
Manufacturer	Global Medicine
Packaging	Bottle
Strength	6.25mg/10mg/5Ml Bottle 480ml (8 fl. oz. ) (Purple Color)
Delivery Time	7 To 10 Days
SKU:	PROMITHEZINE CODEINE (Generic)

 

Promethazine + Codeine (Generic)

What is it?

• Promethazine with Codeine is a combination medication.

• It contains Promethazine hydrochloride (an antihistamine) and Codeine (a narcotic cough suppressant).

• Usually comes in syrup form.

• It is prescription-only in most countries because of the risks associated with Codeine (an opioid).

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Medical Uses (Benefits)

Doctors prescribe this combination for:

• Relief of cough caused by colds, flu, or upper respiratory infections.

• Relief of allergy symptoms like runny nose, sneezing, or itching.

• Sedation and nausea reduction (from Promethazine).

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How It Works

• Promethazine: Blocks histamine (H1) receptors → reduces allergy symptoms and causes sedation.

• Codeine: Works on the brain’s cough center → suppresses coughing; also provides mild pain relief.

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Benefits (When Used Correctly)

• Effective in controlling severe cough that disturbs sleep.

• Provides allergy symptom relief.

• The combination helps people with persistent cough + allergic symptoms.

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Harms & Risks

• Addiction & Misuse – Codeine is an opioid, so long-term use or abuse can lead to dependence.

• Side Effects: drowsiness, dizziness, blurred vision, dry mouth, constipation, nausea.

• Respiratory Depression – high doses can slow breathing (especially dangerous in children or when mixed with alcohol/other sedatives).

• Overdose Risk – can cause unconsciousness or death if misused.

• Recreational Abuse – Often misused in drinks (known as “Lean” or “Purple Drank”), making it a controlled substance in the U.S. and many countries.

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Conclusion

• Promethazine + Codeine is a useful cough syrup for short-term relief of severe cough and allergy symptoms.

• However, because Codeine is an opioid, this medicine has a high risk of misuse, addiction, and overdose.

• That’s why it is strictly regulated and only prescribed when necessary.

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